Traditionally, the function of proteins has been intimately linked to their three-dimensional structure. However, as early as in the 1990s, a novel class of functional proteins lacking a well-defined three-dimensional structure was discovered. This new class of proteins is known as intrinsically disordered proteins (IDPs).
The role of IDPs in human diseases is now well recognized, and their relevance has boosted the development of new strategies and technologies, and drug discovery in IDPs is today within reach.
Disease-associated IDPs are novel, promising targets for drug discovery.