Intrinsically Disordered Proteins: Dynamics, Binding, and Function thoroughly examines and ties together the fundamental biochemical functions of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs), including signaling, binding, and regulation, with the methodology for study and the associated pathways for drug design and therapeutic intervention. The role of new mechanistic, computational, and experimental approaches in IDP study are explored in depth, with methods for the characterization of IDP dynamics; models, simulations, and mechanisms of IDP and IDR binding; and biological and medical implications of IDP dynamics prominently featured. Written and edited by leading scientists in the field, this book explores groundbreaking areas such as ensemble descriptions of IDPs and IDRs, single-molecule studies of IDPs and IDRs, IDPs and IDRs in membraneless organelles, and molecular mechanisms of fibrillation of IDPs.

Intrinsically Disordered Proteins provides students and researchers in biochemistry, molecular biology, and applied microbiology with a comprehensive and updated discussion of the complex dynamics of IDPs and IDRs.
Table of Contents

CHAPTER 1 Introduction to intrinsically disordered proteins and regions

PART I – Methodology
CHAPTER 2 Ensemble descriptions of IDPs and IDRs: Integrating simulation and experiment
CHAPTER 3 Experimental characterization of the dynamics of IDPs and IDRs by NMR
CHAPTER 4 Single-molecule fluorescence studies of IDPs and IDRs

PART II – Molecular Mechanism
CHAPTER 5 Experimental studies of binding of intrinsically disordered proteins to their partners
CHAPTER 6 Modeling protein-protein interactions with intrinsically disordered proteins

PART III – Biology and Medicine
CHAPTER 7 IDPs and IDRs in biomolecular condensates
CHAPTER 8 Molecular mechanisms of fibrillation of IDPs
CHAPTER 9 Perspectives on drug discovery strategies based on IDPs (Contributed by IDP Pharma)
CHAPTER 10 Conclusion and future directions