Intrinsically Disordered Proteins: Dynamics, Binding, and Function thoroughly examines and ties together the fundamental biochemical functions of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs), including signaling, binding, and regulation, with the methodology for study and the associated pathways for drug design and therapeutic intervention. The role of new mechanistic, computational, and experimental approaches in IDP study are explored in depth, with methods for the characterization of IDP dynamics; models, simulations, and mechanisms of IDP and IDR binding; and biological and medical implications of IDP dynamics prominently featured. Written and edited by leading scientists in the field, this book explores groundbreaking areas such as ensemble descriptions of IDPs and IDRs, single-molecule studies of IDPs and IDRs, IDPs and IDRs in membraneless organelles, and molecular mechanisms of fibrillation of IDPs.

Intrinsically Disordered Proteins provides students and researchers in biochemistry, molecular biology, and applied microbiology with a comprehensive and updated discussion of the complex dynamics of IDPs and IDRs.
Table of Contents

CHAPTER 1 Introduction to intrinsically disordered proteins and regions

PART I – Methodology
CHAPTER 2 Ensemble descriptions of IDPs and IDRs: Integrating simulation and experiment
CHAPTER 3 Experimental characterization of the dynamics of IDPs and IDRs by NMR
CHAPTER 4 Single-molecule fluorescence studies of IDPs and IDRs

PART II – Molecular Mechanism
CHAPTER 5 Experimental studies of binding of intrinsically disordered proteins to their partners
CHAPTER 6 Modeling protein-protein interactions with intrinsically disordered proteins

PART III – Biology and Medicine
CHAPTER 7 IDPs and IDRs in biomolecular condensates
CHAPTER 8 Molecular mechanisms of fibrillation of IDPs
CHAPTER 9 Perspectives on drug discovery strategies based on IDPs (Contributed by IDP Pharma)
CHAPTER 10 Conclusion and future directions

Bio€quity 2019, the most important biopharmaceutical investor conference in Europe, will take place in Barcelona for the first time on May 20-21, 2019. IDP Pharma will attend The meeting and present the company to investors. Organized by BioCentury and EBD Group is the seminal industry event for financial dealmakers looking for investor-validated life science companies positioning themselves to attract capital, and for pharmaceutical licensing professionals to assess top prospects.

Bio€quity Europe has showcased more than 800 leading European companies to thousands of investment and pharma business development professionals.

IDP Pharma will attend The BIO-Spain in Sevilla (September 25th-27th, 2018). BIOSPAIN is the largest biotech event organized by a national bioindustry association in Europe and one of the largest in the world by the number of one-to-one meetings (+3.000) and companies participating (+800).

IDP Pharma will attend the Annual Meeting of the American Association for Cancer Research (14 -18 Apr 2018). The Meeting will take place at McCormick Place North/South in Chicago , Illinois USA. AACR 2018, Annual Meeting of the American Association for Cancer Research is going to be dealing with Medical, Health Care, Oncology and Cancer.

IDP Pharma will attend next 11th Annual European Life Sciences CEO Forum & Exhibition. This event is being held on 26th-27th February 2018 at the Hilton Zurich Airport Hotel, Switzerland, and organized by Sachs Associates. IDP Pharma will be also one of the presenting companies.

This event will be highly transactional, bringing together an exciting cross-section of venture-funded and small-cap companies with leading investors, pharmas, and scientific thought leaders. It is expected over 350 delegates and 70+ presenting companies. Event’s networking will be powered by online One-2-One meeting system and dedicated meeting facilities to make the event more transactional and productive. We hope to see you there!